An in silico based characterization and analysis of Human matrix metalloproteinases (MMPs)

Abstract

Background and aims: Potentially involved proteins which are implicated as a specific target for any diseased condition may
implicate certain unusual features in several pathological conditions. Human Matrix metalloproteinase (MMP) family of
endopeptidases is one such family responsible for many beneficial as well as several pathological critical diseases. With the advent
of field of bioinformatics and computational efforts can aid researchers to comprehend their system of work. Methodology: An
insilico characterization of the MMP family has been carried out to analyze their primary, secondary, structural and functional
perspective . The research has been focused on specific MMPs in which the further study was based on Mutational analysis
confirming the pathogenicity of MMPs in cancer metastasis. The basic approach was to screen large protein families which plays
dual role during normal and diseased conditions. Results: Thus it is hypothesized that cysteine rich and highly thermostable
MMPs might be key players in diseased conditions. Conclusion: It can also be concluded that the disease responsive MMPs might
be considered as promising targets for treatment of cancer.